Plasma from Young Mice Reverses Aging in Old Mice

A new study suggests the possibility of slowing, and perhaps even reversing, the aging process.
The study, published in the journal "Nature Aging," showed that infusion of "small extracellular vesicles" (sEVs) from the blood of young mice can rejuvenate the brain, liver, bones, skeletal muscles, pancreas, and heart of old mice.

What are sEVs?

sEVs are nano-vesicles secreted by cells and contain various substances, such as proteins, nucleic acids, and micro-RNA.
They serve as intercellular messengers, carrying information and contributing to the normal function of many systems in the body.

Study Findings:

• Infusion of young sEVs into old mice significantly increased their lifespan by 12.4%.
• Treatment with young sEVs improved many physiological functions, including cognitive function, liver health, bone density, muscle health, pancreatic function, and heart function.
• Testosterone levels, sperm count, sperm motility, and sperm chromatin integrity increased in male mice treated with young sEVs.
• Fertility of female mice treated with young sEVs improved.

Mechanism of Action:

The exact mechanism by which young sEVs cause rejuvenation is not yet fully understood.
However, the researchers believe that sEVs may transfer substances that promote cell regeneration, DNA repair, and improved mitochondrial function.

Old Mice Treated with Young sEVs: Summary of Additional Findings

Improved Metabolic Health:

• Higher oxygen consumption and carbon dioxide production
• Significant improvement in echocardiogram parameters
• Improvement in bone architecture
• Cortical atrophy decreased after treatment

Reduction in Aging Markers:

• SA-β-gal levels decreased in various organs
• Reactive oxygen species (ROS) levels returned to levels of young mice
• Accumulation of advanced glycation end-products was eliminated

References:
https://www.nature.com/articles/s43587-024-00612-4